IGF-1
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How is it used?IGF-1 is measured to help diagnose the cause of growth abnormalities and to evaluate pituitary function. It is not diagnostic of GH deficiency but may be ordered along with GH stimulation tests to offer additional information. IGF-1 levels and the measurement of GH can also provide information related to GH insensitivity.
IGF-1 may be ordered with other pituitary hormone tests, such as adrenocorticotropic hormone (ACTH), to help diagnose hypopituitarism. It may be used to monitor the effectiveness of treatment for growth hormone deficiencies and growth hormone insensitivity.
IGF-1 testing and a GH suppression test can be used to detect a GH-producing pituitary tumor. Its presence is then confirmed with imaging scans that help identify and locate the tumor. If surgery is necessary, GH and IGF-1 levels are measured after the tumors removal to determine whether or not all of it was successfully removed. Drug and/or radiation therapy may be used in addition to (or sometimes instead of) surgery to try to decrease GH production and return IGF-1 to normal or near normal concentrations. IGF-1 may be used to monitor the effectiveness of this therapy at regular intervals for years afterward to monitor GH production and to detect tumor recurrence.
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When is it ordered?IGF-1 testing may be ordered, along with a GH stimulation test, when a child has symptoms of GH deficiency, such as a slowed growth rate and short stature. They also may be ordered when adults have symptoms that the doctor suspects may be due to a GH deficiency. An IGF-1 also may be ordered when a doctor suspects that a person has an underactive pituitary gland and at intervals to monitor patients on GH therapy.
IGF-1 testing may be ordered, along with a GH suppression test, when a child has symptoms of gigantism, an adult shows signs of acromegaly, and/or when a doctor suspects that a patient has hyperpituitarism.
When a GH-producing pituitary tumor is found, GH and IGF-1 are ordered after the tumor is surgically removed to determine whether all of the tumor has been extracted. IGF-1 also is ordered at regular intervals when a patient is undergoing the drug and/or radiation therapy that frequently follow tumor surgery.
IGF-1 levels may be ordered at regular intervals for many years to monitor a patients GH production and to watch for pituitary tumor recurrence.
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What does the test result mean?Normal concentrations of IGF-1 must be considered in context. Some patients can have a GH deficiency and still have a normal IGF-1 concentration.
Decreased IGF-1
If IGF-1 concentrations are decreased, then it is likely that there is a deficiency of GH (GH Deficiency; GHD) or an insensitivity to GH. If this is in a child, the GH deficiency may have already caused short stature and delayed development and may be treated with GH supplementation. Adults will have an age-related decrease in production, but lower than expected concentrations may reflect a GH deficiency or insensitivity.If a decrease in IGF-1 is due to a more general decrease in pituitary function (hypopituitarism), then several of the patients pituitary hormones will need to be evaluated and may be supplemented to bring them up to normal levels. Reduced pituitary function may be due to inherited defects or can rise as a result of pituitary damage following conditions such as trauma, infections, and inflammation.
Decreased levels of IGF-1 also may be seen with nutritional deficiencies (including anorexia nervosa), chronic kidney or liver disease, inactive/ineffective forms of GH, and with high doses of estrogen.
Increased IGF-1
Elevated levels of IGF-1 usually indicate an increased production of GH. Since GH levels vary throughout the day, IGF-1 concentrations are a reflection of average GH production, not of the actual amount of GH in the blood. This is accurate up to the point at which the livers capacity to produce IGF-1 is reached. With severely increased GH production, IGF-1 levels will stabilize at an elevated maximum concentration.Increased concentrations of GH and IGF-1 are normal during puberty and pregnancy but otherwise are most frequently due to pituitary tumors (usually benign). If other pituitary hormones are also abnormal, then the patient may have a condition causing general hyperpituitarism.
If IGF-1 is still elevated after the surgical removal of a pituitary tumor, then the surgery may not have been fully effective. Decreasing IGF-1 concentrations during subsequent drug and/or radiation therapies indicate that the treatment is lowering GH production. If levels of IGF-1 become normalized, then the patient is no longer producing excess amounts of GH. When a patient is undergoing long term monitoring, an increase in IGF-1 levels may indicate a recurrence of the pituitary tumor.
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Is there anything else I should know?
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What signs and symptoms are seen with deficient GH and IGF-1?In children, the following may indicate GH and/or IGF-1 deficiency:
- Slowed growth rate in early childhood relative to group norms
- Shorter stature than others of the same chronological age
- Delayed puberty
- x-rays showing delayed bone development.
In adults, abnormally low levels of GH and/or IGF-1 may cause subtle, nonspecific symptoms such as:- Decreased bone density
- Fatigue
- Adverse lipid changes
- Reduced exercise tolerance.
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What signs and symptoms are seen with excess GH and IGF-1 production?In a child, it is unusual tallness that is often first noticed. With an adult, it may be more subtle: a larger nose, thicker lips, a more prominent jaw, or rings and shoes that no longer fit. Other signs and symptoms may include:
- Deepened, husky voice
- Enlarged organs - liver, heart, kidneys, and spleen
- Enlarged tongue
- Erectile dysfunction
- Fatigue
- Headaches and visual disturbances
- Joint pain and swelling
- Menstrual cycle irregularities
- Muscle weakness
- Snoring
- Sweating and body odor
- Thickening of the skin, skin tags
- Trapped nerves (Carpal tunnel syndrome)
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How long do I have to be monitored?